Ordering the Pernicious Anemia Diagnostic Panel
The Pernicious Anemia Diagnostic Panel helps check for causes of vitamin B12 deficiency, which can lead to symptoms like tiredness, numbness, and memory problems. This test looks at key markers, including intrinsic factor blocking antibody, methylmalonic acid, and vitamin B12, to help find out if your body is having trouble absorbing B12 or if your immune system is affecting your stomach’s ability to make red blood cells. Interestingly, some people with this condition may first notice changes in mood or balance before any blood changes are seen.
Ordering this panel can help you:
- Find out if your body is not absorbing vitamin B12 properly
- Detect early signs of nerve damage before symptoms get worse
- Check for autoimmune reactions that may be affecting your stomach
- Identify if high methylmalonic acid is linked to B12 deficiency
- Get clear answers about unexplained tiredness or memory loss
Who Should Consider Autoimmune Anemia and B12 Deficiency Testing
People who have ongoing tiredness, tingling in their hands or feet, or trouble remembering things may benefit from this test. For example, someone who has been feeling more forgetful and weak, and has noticed pale skin and trouble with balance, could use this panel to find out if low B12 or an autoimmune problem is the cause.
Ordering this test may also be helpful if you:
- Have a family member with autoimmune conditions or B12 deficiency
- Follow a strict vegetarian or vegan diet and feel tired or dizzy
- Experience digestive problems like bloating or frequent stomach upset
- Notice mood changes, such as feeling more irritable or sad than usual
- Recently had unexplained nerve pain or tingling after a stomach infection
Testing can help you find out if your body is making enough healthy red blood cells and if your nerves are at risk for damage from low B12. Waiting to order this test could mean missing the chance to catch nerve problems early, which may be harder to treat if found later.
Preparing for Vitamin B12 and Intrinsic Factor Antibody Testing
Fasting is not needed for this test, so you can eat and drink as usual before your blood draw. Always follow any instructions your doctor or healthcare provider gives you to make sure your sample is collected the right way.
Labs Included When Ordering Your Pernicious Anemia Diagnostic Panel
| Test Name | Reference Range | What This Marker Means | Low and High Levels of This Marker |
|---|---|---|---|
| Intrinsic Factor Blocking Antibody | Negative | This test checks for antibodies that block the absorption of vitamin B12 in the stomach. It helps find out if your immune system is causing B12 deficiency. |
High levels mean your immune system may be stopping your body from absorbing vitamin B12.
Low levels mean your immune system is not blocking B12 absorption. |
| Methylmalonic Acid | 73–271 | Methylmalonic acid is a substance that builds up when vitamin B12 is low. This marker helps show if your body has enough B12 for healthy nerve and blood cell function. |
High levels mean you may have a vitamin B12 deficiency.
Low levels mean your vitamin B12 levels are likely normal. |
| Vitamin B12 | 200–1100 | Vitamin B12 is needed for making red blood cells and keeping nerves healthy. This test shows if you have enough B12 in your blood. |
High levels mean you may be taking too much B12 or have a liver problem.
Low levels mean you may not be getting or absorbing enough B12. |
Reference ranges may change slightly over time as labs update their methods and guidelines.
Pernicious Anemia Diagnostic Panel FAQ
Is there Pernicious Anemia Diagnostic Panel testing near me?
This test kit can be collected at a local draw site, which you can find using the draw location link above. Since symptoms like numbness or memory changes can make travel difficult, having a nearby collection site makes it easier to get tested quickly and comfortably.
How do I interpret the test results?
While your treating physician should review your results, you can also use our one-on-one test results review service for a detailed explanation from our clinical team.
What is the cost of the test?
The price you see includes standard shipping to you and back to the lab, but local draw fees may apply. Ordering this test can help you find out if B12 deficiency is causing your symptoms, so you can start the right treatment sooner.
How often should I retest?
Retesting is usually recommended every 6 to 12 months, especially if you have ongoing symptoms or are being treated for B12 deficiency. Regular testing helps track changes and makes sure your treatment is working as expected.
How accurate is the test?
This panel uses immunoassay and liquid chromatography-tandem mass spectrometry (LC-MS/MS) for high precision, with specificity and sensitivity both above 98%. TrueHealthLabs.com partners with CLIA-certified and CAP-certified laboratories to uphold rigorous testing standards for dependable results.
Important Notes
- This test cannot be collected in NY, NJ, MA, and RI. Contact us with questions.
- Samples should not be collected if you received a vitamin B12 injection therapy within the past week.
Medical Review Board
Reviewed by Jeff Donohue M.D. from Body Logic and Brady Hurst DC, CCCN. Written by True Health Lab’s team of editorial health contributors.
Disclaimer: This information is for educational purposes only and not intended as medical advice. Consult your healthcare provider for personalized guidance.
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