Ordering the Neurofilament Light Chain (NFL), Blood Test
Neurofilament Light Chain (NFL), Serum is a blood test that measures the amount of a specific protein released when nerve cells in the brain or spinal cord are damaged. This test is often used to help track changes in brain conditions such as multiple sclerosis, Alzheimer’s, Parkinson’s, and traumatic brain injury. Interestingly, research shows that NFL levels can rise years before symptoms of some neurological diseases appear, making it a useful marker for early changes in nerve health.
Ordering this test can help you:
- Track nerve cell damage over time to monitor disease progression or response to treatment
- Detect early signs of neurodegeneration before symptoms become noticeable
- Distinguish between different types of neurological disorders for more targeted care
- Assess the impact of a recent concussion or traumatic brain injury
- Support decisions about starting, stopping, or changing medications for brain-related conditions
Who Should Consider Nerve Damage and Brain Health Testing
People who have noticed changes in memory, thinking, or movement, or who have a family history of neurological conditions, may benefit from this test. For example, someone who has recently experienced a mild head injury and is worried about long-term effects may want to check for hidden nerve damage.
Ordering this test may also be helpful in these situations:
- Tracking changes in someone with a diagnosis of multiple sclerosis or another neurodegenerative disease
- Monitoring brain health after a sports-related concussion
- Checking for nerve damage in people with unexplained memory loss or confusion
- Evaluating the effects of new treatments for Parkinson’s or Alzheimer’s disease
- Assessing nerve health in people with chronic inflammation or autoimmune conditions, as these can sometimes affect the brain
Testing for this marker can help identify nerve cell damage early, guide treatment choices, and provide a clear picture of how a condition is changing over time. Delaying this test could mean missing important changes that may affect treatment decisions or long-term outcomes.
How to Prepare for the Test
Fasting is not required for this test, but you should avoid taking biotin supplements for 72 hours before your blood draw. Always follow any instructions or special guidance your doctor or healthcare provider gives you to make sure your sample is collected correctly and your results are as useful as possible.
Labs Included When Ordering Your Neurofilament Light Chain (NFL), Serum Test
| Test Name | Reference Range | What This Marker Means | Low and High Levels of Neurofilament Light Chain (NFL), Serum |
|---|---|---|---|
| Neurofilament Light Chain (NFL) | <18 | Neurofilament Light Chain is a protein released into the blood when nerve cells are damaged. It is used to detect and monitor nerve injury or degeneration in the brain and spinal cord. | High levels mean there may be active nerve cell damage, which can be seen in conditions like multiple sclerosis, Alzheimer’s, Parkinson’s, or after a brain injury.
Low levels mean there is little or no evidence of nerve cell damage at the time of testing. |
Reference ranges may change slightly as labs update their methods or as new research becomes available. Always check your report for the most current information.
Neurofilament Light Chain (NFL), Serum FAQ
Is there Neurofilament Light Chain (NFL), Serum testing near me?
This test is provided as a kit that can be collected at a local blood draw site—see the draw location link at the top of the page. For people monitoring brain changes or nerve injury, having a nearby collection site makes it easier to get tested quickly and track changes over time.
How do I interpret the test results?
While your treating physician should review your results, you can also use our one-on-one test results review service with our clinical team for a detailed explanation and next steps.
What is the cost of the test?
The price listed for this test includes standard shipping to you and return shipping to the lab, but local draw fees may apply. Testing for nerve cell damage can help you and your doctor make faster, more informed decisions about managing symptoms or tracking recovery.
How often should I retest?
Retesting is usually recommended every 6 to 12 months for people with ongoing neurological conditions or after a brain injury, as this helps track changes and guide treatment adjustments.
How accurate is the test?
This test uses an ultrasensitive immunoassay method (such as Simoa) with a specificity of 98% and a sensitivity of 97% for detecting nerve cell damage. TrueHealthLabs.com partners with CLIA-certified and CAP-certified laboratories to uphold rigorous testing standards for dependable results.
Important Notes
- This test is not available in NY, NJ, MA, and RI. Contact us with questions.
Medical Review Board
Reviewed by Jeff Donohue M.D. from Body Logic and Brady Hurst DC, CCCN. Written by True Health Lab’s team of editorial health contributors.
Disclaimer: This information is for educational purposes only and not intended as medical advice. Consult your healthcare provider for personalized guidance.
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