Ordering the Matrix metalloproteinase-9 (MMP-9) Test
Matrix metalloproteinase-9 (MMP-9) is a protein released by certain white blood cells that helps break down vessel walls, allowing substances to move into tissues like the brain, muscles, and joints. This test measures the amount of MMP-9 in your blood, which can help identify if your body is experiencing ongoing tissue breakdown or inflammation. Interestingly, research shows that MMP-9 levels can rise before symptoms appear in some chronic conditions, making early detection possible.
Ordering this test can provide specific benefits:
- Detects abnormal tissue breakdown linked to joint pain, skin issues, and digestive problems.
- Helps monitor inflammation in chronic conditions such as Crohn’s disease, ulcerative colitis, and psoriasis.
- Assists in tracking the effectiveness of treatments for autoimmune or cardiovascular diseases.
- Identifies early signs of plaque buildup in blood vessels, which may lead to heart disease.
- Supports evaluation of unexplained chronic pain or neurological symptoms.
Who Should Consider This Inflammation and Tissue Breakdown Test
People who have ongoing joint pain, skin rashes, or digestive discomfort that does not improve with standard care may benefit from this test. For example, someone who has tried several treatments for eczema or psoriasis but still experiences flare-ups could use this test to check for hidden inflammation.
Ordering this test may also be helpful in these situations:
- Persistent respiratory issues that do not respond to usual therapies
- Unexplained muscle weakness or chronic fatigue
- Monitoring after a recent brain injury or concussion
- Tracking changes in autoimmune disease activity
- People with a family history of early heart disease who want to check for early vessel changes
This test is recommended for those who want to measure inflammation and tissue breakdown, which can help guide treatment decisions and track progress. Delaying this test could mean missing early changes that are easier to address before they lead to more severe symptoms or complications.
How to Prepare for the Test
Fasting is not required for the MMP-9 blood test, so you can eat and drink as usual before your appointment. Always follow any specific instructions your doctor or healthcare provider gives you to make sure your sample is collected correctly and your results are as useful as possible.
Labs Included When Ordering Your Matrix metalloproteinase-9 (MMP-9) Test
| Test Name | Reference Range | What This Biomarker Means | Low and High Levels of Matrix metalloproteinase-9 (MMP-9) |
|---|---|---|---|
| MMP-9 | 15-85 | MMP-9 is an enzyme that helps break down the extracellular matrix, which supports tissue repair and immune response. High levels are linked to inflammation, tissue damage, and chronic disease activity. |
High levels mean there may be ongoing inflammation, tissue breakdown, or increased risk for conditions like arthritis, cardiovascular disease, or autoimmune disorders.
Low levels mean the body is not actively breaking down tissue, which is usually normal unless there are symptoms of poor wound healing. |
Reference ranges may change slightly as labs update their standards, so always check your report for the most current values.
Matrix metalloproteinase-9 (MMP-9) FAQ
Is there Matrix metalloproteinase-9 (MMP-9) testing near me?
This test is provided as a kit that you can take to a local draw site—see the draw location link at the top of the page. For people managing ongoing inflammation or tissue damage, having a nearby collection site makes it easier to get tested without added stress or travel.
How do I interpret the test results?
While your treating physician should review your results, you can also use our one-on-one test results review service with our clinical team for a detailed explanation and next steps.
What is the cost of the test?
The price listed for this test includes standard shipping to you and return shipping to the lab, though draw fees may apply at your local collection site. Ordering this test can help you identify inflammation or tissue breakdown early, which may help you address symptoms and recover more quickly.
How often should I retest?
Retesting every 3 to 6 months is recommended if you are monitoring a chronic condition or tracking treatment progress. Regular testing helps you and your provider see if inflammation is improving or if changes in your care plan are needed.
How accurate is the test?
This test uses an enzyme-linked immunosorbent assay (ELISA) method, which is highly specific and sensitive for detecting MMP-9 in blood. The test has a specificity of 98% and a sensitivity of 97%. TrueHealthLabs.com partners with CLIA-certified and CAP-certified laboratories to uphold rigorous testing standards for dependable results.
Important Notes
- This test is not available in NY, NJ, MA, and RI. Contact us with questions.
Medical Review Board
Reviewed by Jeff Donohue M.D. from Body Logic and Brady Hurst DC, CCCN. Written by True Health Lab’s team of editorial health contributors.
Disclaimer: This information is for educational purposes only and not intended as medical advice. Consult your healthcare provider for personalized guidance.
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