Ordering the Hormones Comprehensive Plus Panel | Great Plains | Canada
This panel measures key hormone levels to help identify imbalances that may affect energy, mood, menstrual cycles, and reproductive function. It is especially useful for tracking changes related to menopause, polycystic ovary syndrome (PCOS), and other hormone-related conditions. Interestingly, hormone levels can shift throughout the day, so this test collects samples at different times to give a more complete picture.
Ordering this test can help you:
- Pinpoint hormone imbalances that may be linked to symptoms like fatigue, hair loss, or irregular periods
- Track estrogen, progesterone, and testosterone levels to support fertility planning or menopause management
- Monitor cortisol patterns to better understand chronic stress or adrenal fatigue
- Detect early signs of metabolic syndrome or insulin resistance
- Guide treatment decisions for conditions like endometriosis or estrogen dominance
Who Should Consider Comprehensive Hormone Testing
People who have been feeling unusually tired, experiencing mood swings, or noticing changes in their menstrual cycle may benefit from this test. For example, someone who has been struggling with night sweats, weight gain, and trouble sleeping might find answers by checking their hormone levels.
Ordering this test may also be helpful if you:
- Have symptoms of menopause, such as hot flashes or low libido
- Are trying to conceive and want to check for hormone-related fertility issues
- Experience unexplained hair loss or skin changes
- Have a history of osteoporosis or bone loss
- Notice mood changes that seem to follow a pattern each month, which can sometimes be linked to hormone shifts
Testing can reveal specific hormone patterns that may be causing symptoms like irregular periods, sleep problems, or changes in energy. Delaying this test could mean missing the chance to address hormone imbalances before they start to affect bone strength, metabolism, or reproductive health.
Preparing for a Multi-Hormone Panel
Fasting is not required for this saliva-based test, but it is important to collect samples at the times listed in the kit instructions. Always follow the directions provided by your doctor or healthcare practitioner to make sure your samples are collected correctly and your results are as useful as possible.
Labs Included When Ordering Your Hormones Comprehensive Plus Panel by Great Plains
| Test Name | Reference Range | What This Marker Means | Low and High Levels of This Marker |
|---|---|---|---|
| Estrogen Markers | |||
| Estradiol | 1.3 – 3.3 pg/mL (saliva, premenopausal, luteal phase) | Estradiol is the main form of estrogen in women and plays a key role in regulating the menstrual cycle and supporting bone strength. It also affects mood and energy. |
High levels mean possible estrogen dominance, which can cause heavy periods, weight gain, or breast tenderness.
Low levels mean possible menopause, missed periods, or increased risk of bone loss. |
| Estrone | 0.5 – 1.2 pg/mL (saliva, premenopausal) | Estrone is another type of estrogen that becomes more important after menopause. It helps balance other hormones and supports tissue health. |
High levels mean possible increased risk for estrogen-related conditions, such as endometriosis or certain cancers.
Low levels mean possible hormone deficiency, which may affect bone and tissue health. |
| Estriol | 0.5 – 1.5 pg/mL (saliva, premenopausal) | Estriol is a weaker estrogen that helps protect tissues and is especially important during pregnancy. It also helps balance stronger estrogens. |
High levels mean possible hormone imbalance, sometimes seen in pregnancy or with certain supplements.
Low levels mean possible low estrogen activity, which may affect vaginal and urinary tract health. |
| Other Hormones | |||
| Progesterone | 75 – 270 pg/mL (saliva, luteal phase) | Progesterone helps prepare the body for pregnancy and balances the effects of estrogen. It also supports sleep and mood stability. |
High levels mean possible ovarian cysts or hormone therapy effects.
Low levels mean possible irregular periods, trouble staying pregnant, or sleep problems. |
| Testosterone | 16 – 55 pg/mL (saliva, adult women) | Testosterone supports muscle strength, energy, and sex drive. It also helps maintain bone density and mood balance. |
High levels mean possible PCOS, acne, or unwanted hair growth.
Low levels mean possible low energy, reduced muscle mass, or decreased sex drive. |
| DHEA | 130 – 980 pg/mL (saliva, adult women) | DHEA is a hormone made by the adrenal glands that helps produce estrogen and testosterone. It supports energy, immune function, and stress response. |
High levels mean possible adrenal overactivity or hormone supplementation.
Low levels mean possible adrenal fatigue, low energy, or mood changes. |
| Adrenal Hormones | |||
| Cortisol (4x a day) | Morning: 3.7 – 9.5 ng/mL Noon: 1.2 – 3.0 ng/mL Evening: 0.6 – 1.9 ng/mL Night: 0.4 – 1.0 ng/mL |
Cortisol is the main stress hormone and is measured at four times during the day to track daily patterns. It helps control energy, sleep, and the body’s response to stress. |
High levels mean possible chronic stress, sleep problems, or adrenal gland issues.
Low levels mean possible adrenal fatigue, low energy, or trouble handling stress. |
Reference ranges may change slightly as labs update their methods or as new research becomes available.
Hormones Comprehensive Plus Panel FAQ
Is there Hormones Comprehensive Plus Panel testing near me?
This is a home test kit that you can collect yourself, and you can find a local draw location using the link at the top of the page. For people experiencing symptoms like irregular periods or fatigue, being able to collect your sample at home or nearby makes it easier to get answers without extra travel or waiting.
How do I interpret the test results?
While your treating physician should review your results, we also offer a one-on-one test results review with our clinical team to help you understand your hormone levels and what they mean for your symptoms.
What is the cost of the test?
The price listed for this test includes standard shipping to you and return shipping to the lab, but draw fees may apply if you use a collection site. Ordering this test can help you quickly identify hormone imbalances that may be causing symptoms like fatigue or mood changes, so you can start targeted treatment sooner.
How often should I retest?
Retesting is usually recommended every 3 to 6 months, especially if you are starting or changing hormone therapy, or if your symptoms change. Regular testing helps track how your hormone levels respond to treatment and can guide any needed adjustments.
How accurate is the test?
This test uses saliva samples analyzed by enzyme immunoassay (EIA), which is highly specific for measuring free hormone levels. The test has a specificity of 98% and a sensitivity of 97%. TrueHealthLabs.com partners with CLIA-certified and CAP-certified laboratories to uphold rigorous testing standards for dependable results.
Important Notes
- This test can not be collected or mailed from New York State. Contact us with questions.
Medical Review Board
Reviewed by Jeff Donohue M.D. from Body Logic and Brady Hurst DC, CCCN. Written by True Health Lab’s team of editorial health contributors.
Disclaimer: This information is for educational purposes only and not intended as medical advice. Consult your healthcare provider for personalized guidance.
Why Customers Trust True Health Labs – What People are saying
Also rated 4.6 out of 5 based on 3452 ShopperApproved reviews- See all TrueHealthLabs.com reviews.
